Curriculum Vitae

Personal Details

Name Hashim Shams

Date of birth 19.8.1951

Nationality Afghan / German

Education

1974 - 1982 Physics and Medicine at Ruhr-Universität Bochum

and Universität Essen, Germany

1982 M.D. Ruhr-Universität Bochum

1990 Ph.D Ruhr-Universität Bochum

Professional Appointments

1982 Postdoctoral fellow at the Department of Physiology, Medical School, Ruhr-Universität Bochum

1986 Postdoctoral fellow at the University of California, San Diego, La Jolla, USA

1986 Dissertation (Dr. med.), Ruhr-Universität Bochum

October 1986 Scientific Prize for Top grade Dissertation (Summa cum laude), Ruhr-Universität Bochum

December 1990 Habilitation and "VENIA LEGENDI", Approved

Certificate to be Professor in Physiology

1996 State approval as specialist for Physiology

1996 to 2007 Professor in Physiology, Medical Faculty,

Ruhr-Universität Bochum

1998 Guest Professor at the Case Western Reserve

University, Cleveland Ohio, USA

2007 to 2008 Professor of Physiology, Ross University School of Medicine, Dominica, West Indies

9/2008 Professor of Physiology, University of Medicine and Health Sciences, St. Kitts, West Indies

Membership in Societies

· American Physiological Society

· Deutsche Physiologische Gesellschaft

· European Society for Comparative Physiology and Biochemistry

Main research Areas

· Control of breathing: Central chemosensitivity

· Gas Exchange (Alveolar; Blood gas transport; Tissue respiration)

· Comparative Physiology (Models for vertebrate gas exchange, Hypoxia tolerance)

· Mechanical Ventilation (Inspiratory pressure support ventilation)

External scientific cooperation with

· Dr. Frank Powell

Department of Medicine

University of California San Diego

9500 Gilman Drive 0623A, La Jolla, CA 92093-0623, USA

· Dr. Nanduri R. Parabhakar

Vice Chair of Department of Physiology and Biophysics

School of Medicine, Case Western Reserve University

10900 Euclid Avenue

Cleveland, OH 44106-4970, USA

· Dr. James A. Orr

Division of Biological Sciences

The University of Kansas

1200 Sunnyside Ave, Haworth Hall, Biol. Sci

Lawrence, KS 66045-7534, USA

· Dr. Sukhamay Lahiri

Department of Physiology

University of Pennsylvania Med Ctr, 37^th Hamilton Walk

B-201 Richards Building

Philadelphia, PA 19104-6085, USA

· Dr. Johannes Piiper

Former Director of Max-Planck-Institut für experimentelle Medizin

Hermann-Rein-Str. 3

37075 Göttingen

Administrative Responsibilities

Served as a member in the following commissions of the medical Faculty:

· Commission for approval of Dissertations

· Commission for approval of Habilitations

· Commission for approval of Apl-Professur

· Commission for educational Program

· Commission for students scholarships (BaföG)

· Representative of the medical faculty in the Senate of Ruhr-uni-Bochum

Publications

Shams, H. (1985). Differential effects of CO2 and H+ as central stimuli of respiration in the cat. J. Appl. Physiol. 58: 357-364.

Shams, H. (1986). Relationship between medullary extracellular pH and respiration during respiratory and metabolic acidosis. Dissertation. Medizinische Fakultät, Ruhr-Universität Bochum.

Orr, J.A., H. Shams, M.R. Fedde and P. Scheid (1986). Addition of HCl to the blood without lowering circulation blood pH increases right ventricular blood pressure and respiratory rate in cats. Prog. Resp. Res. 21: 253-255.

Powell, F.L., H. Shams and S.C. Hempleman (1986). Avian gas exchange in hypoxia at sea level and high altitude. In: Natural History of the White-Inyo Range, and high altitude Physiology: University of California, White Mountain Research Station Symposium. Volume 1, August 23-25, 1985, edited by C.A. Hall and J. Young, jr., pp. 211-215.

Shams, H. and P. Scheid (1987). Respiration and blood gases in the duck exposed to normocapnic and hypercapnic hypoxia. Respir. Physiol. 67: 1-12.

Orr, J.A., H. Shams, M.R. Fedde and P. Scheid (1987). Cardiorespiratory changes during HCl infusion unrelated to decreases in circulation blood pH. J. Appl. Physiol. 62: 2362-2370.

Shams,H ., B.A. Peskar and P. Scheid (1988). Acid infusion elicits thromboxane A2-mediated effects on respiration and pulmonary hemodynamics in the cat. Respir. Physiol. 71: 169-183.

Orr, J.A., M.R. Fedde, H. Shams, H. Röskenbleck and P. Scheid (1988). Absence of CO2-sensitive venous chemoreceptors in the cat. Respir. Physiol. 73: 211-224.

Shams, H., H. Schulz, M. Mohr, H. Kobayashi, U. Mesch, A. Das, P. Scheid and J. Piiper (1989). Cyclooxygenase inhibition and effects of hypoxia on pulmonary circulation and gas exchange in anesthetized dogs. Respir. Physiol. 75: 39-50.

Shams, H. and P. Scheid (1989). Efficiency of parabronchial gas exchange in deep hypoxia: measurements in the resting duck. Respir. Physiol. 77: 135-146.

Shams, H., F.L. Powell and S.C. Hempleman (1989). Effects of normobaric and hypobaric hypoxia on ventilation and arterial blood gases in ducks. Respir. Physiol. 80: 163-170.

Fedde, M.R., J.A. Orr, H. Shams and P. Scheid (1989). Cardiopulmonary function in exercising bar-headed geese during normoxia and hypoxia. Respir. Physiol. 77: 239-252.

Scheid, P., H. Shams and J.Piiper (1989). Gasaustausch bei Wirbeltieren. Verh. Dtsch. Zool. Ges. 82: 57-68.

Powell, F.L., S.C. Hempleman, G.S. Mitchell and H. Shams (1989). Ventilatory acclimatization to high altitude in birds. In: Natural History of the white-Inyo Range, and high altitude Physiology: University of California, White Mountain Research Station Symposium III. edited by C.A. Hall and J. Young, jr.

Shams, H. and P. Scheid (1990). Effects of thromboxane on respiration and pulmonary circulation in the cat: role of the vagus nerve. J. Appl. Physiol. 68: 2042-2046.

Shams, H., J.A. Orr, M.R. Fedde and P. Scheid (1990). Possible pitfalls in the search for arterial and central chemoreception in respiration. In: Arterial Chemoreception, edited by C. Eyzaguirre, S.J. Fidone, R.S. Fitzgerald, S. Lahiri and D.M. McDonald. New York. Heidelberg: Springer Verlag, pp.368-373.

Shams, H.(1990). Thromboxan A₂ und Chemoregulation der Atmung. Habilitationsschrift, Medizinische Fakultät der Ruhr-Universität Bochum.

Scheid, P., H. Shams, W. Karla and J.A. Orr (1992). Acid infusion elicits thromboxane-mediated cardio-respiratory effects. In: Control of Breathing and Its Modeling Perspective, edited by Y. Honda, Y. Miyamoto, K. Konno and J.G. Widdicombe. New York, London, Plenum Press, pp. 71-74.

Karla, W., H. Shams, J.A. Orr and P. Scheid (1992). Effects of the thromboxane A₂ mimetic, U46,619, on pulmonary vagal afferents in the cat. Respir. Physiol. 87: 383-396.

Orr, J. A., H. Shams, W. Karla and P. Scheid (1993). Thromboxane A₂: A novel agent in the control of breathing. Funktionsanalyse biologischer Systeme 23: 31-36.

Shams, H. and P. Sheid (1993). Effects of hypobaria on parabronchial gas exchange in normoxic and hypoxic ducks. Respir. Physiol. 91: 155-163.

Orr, J.A., H. Shams, W. Karla, B.A. Peskar and P. Scheid (1993). Transient ventilatory responses to endotoxin infusion in the cat are mediated by thromboxane A₂. Respir. Physiol. 93: 189-201.

Scheid, P. and H. Shams (1994). Chemosensitivity from the lungs of vertebrates. in: Arterial Chemoreceptors: Cell to System, edited by R.O'Regan et al., New Yark, Plenum Press, pp. 123-132.

Scheid, P. and H. Shams (1994). Das Rätsel des Höhenfluges von Vögeln. RUBIN 1/94: 12-17.

Shams, H. and P. Scheid (1995). Respiratory responses to positive inspiratory pressure in the cat: Effects of CO₂ and vagal integrity. J. Appl. Physiol. 79: 1704-1710.

Herbst, C., B. Tippler, H. Shams and Th. Simmet (1995). A role for endothelin in bicuculline-induced neurogenic pulmonary oedema in rats. Br. J. Pharmacol. 115: 753-760

Scheid, P.,and H. Shams (1995). Höhenflug von Vögeln. Naturw. Rdsch.11: 413-418.

Shams, H., L. Daffonchio and P. Scheid (1996). Effects of levodropropizine on pulmonary afferent C-fibers in the cat. Br. J. Pharmacol.117: 853-858.

Wellner-Kieniz, M.-C. and H. Shams (1998). CO₂-sensitive neurons in organotypic cultures of the fetal rat medulla. Respir. Physiol. 137-151.

Wellner-Kienitz, M.-C., H. Shams and P. Scheid (1998). Contribution of Ca⁺⁺-activated K⁺-channels to central chemosensitivity in cultivated neurons of fetal rat medulla. J. Neurophysiol. 79: 2885-2894.

Wellner-Kienitz, M.-C. and H. Shams (1998). Hyperpolarization-activated inward currents contribute to spontaneous electrical activity and CO₂/H⁺-sensitivity of cultivated neurons of fetal rat medulla. J. Neurosci. 87: 109-121.

Overholt, J.L., E. Ficker, T. Yang, H. Shams, G. R. Bright and N. R. Prabhakar

(2000). Herg-like Potassium current regulates the resting membrane potential in Glomus cells of the rabit carotid body. J. Neurophysiol. 83 (3): 1150-1157.

Roy, A., C. Rozanov, A. Mokashi, P. Daudu, AB. Al-Mehdi, H. Shams and S. Lahiri (2000). Mice lacking in GP91 PHOX Subunit of NAD(P)H Oxidase showed Glomus cell [Ca2+](I) and respiratory responses to hypoxia. Brain Res. 872: 188-193.

Powell, L. F., H. Shams, S.C. Hemplemann and G. Mitchell (2004). Breathing in

thin air: Respiratory acclimatization to altitude in ducks. Respir. Physiol.
Neurobiol. 144: 225-235.

Abstracts

Shams, H., H.R. Ahmad and H.H. Loeschcke (1981). The dependence of ventilation on H+ activity in the extracellular fluid of the Brain in respiratory or metabolic acidosis. Pflügers Arch. 389: R 53.

Scheid, P. J.A. Orr, H. Shams and M.R. Fedde (1985). Acidification of blood with restoration of blood pH increases right ventricular blood pressure and affects ventilation in the cat. Pflügers Arch. 405: R 22.

Orr, J.A., H. Shams, M.R. Fedde and P. Scheid (1986). HCl infusion results in ventilatory and ventilatory and hemodynamic changes unrelated to decreases in circulating blood pH. Fed. Proc. 45: 1003.

Powell, F.L., H. Shams and S.C. Hempleman (1986). Effect of hypobaric and isobaric hypoxia on ventilation and arterial blood gases in ducks. The Physiologist 29: 178.

Fedde, M.R., J.A. Orr, H. Shams and P. Scheid (1986). Blood gas and cardiovascular changes in exercising bar-headed geese breathing normoxic and hypoxic gases. The Physiologist 29: 141.

Fedde, M.R., J.A. Orr, H. Shams and P. Scheid (1986). Pulmonary function and gas exchange in exercising bar-headed geese during normoxia and hypoxia. Poultry Science Association Annual Meeting, August 4-8, 1986.

Shams, H., B.A. Peskar and P. Scheid (1987). Acid/base infusion stimulates thromboxane release with pulmonary hypertension in the cat. Pflügers Arch. 408: R 26.

Orr, J.A., H. Shams, M.R. Fedde and P. Scheid (1987). HCl infusion stimulates the release of a substance from the blood which alters breathing and blood pressure. Oxygen Transfer Symposium, March 27-28. 1987, Kansas City, USA.

Orr, J.R., M.R. Fedde, H. Shams, H. Röskenbleck and P. Scheid (1987). Absence of CO₂-sensitive venous chemoreceptors in the cat. Fed. Proc. 46: 824.

Shams, H., M. Mohr, H. Schulz, H. Kobayashi, U. Mesch, A. Das, J. Piiper and P. Scheid (1988). Effects of hypoxia on pulmonary gas exchange and hemodynamics at inhibited prostanoid synthesis. Pflügers Arch. 411: R 56.

Shams, H., J.A. Orr, M.R. Fedde and P. Scheid (1988). Possible pitfalls in the search for arterial and central chemoreception in respiration. IXth International Symposium on Arterial Chemoreception, Park City, Utah, USA.

Scheid, P., H. Shams, J.A. Orr, M.R. Fedde and H. Röskenbleck (1988). Search for venous chemoreceptors which affects breathing in the cat. Pflügers Arch.411, R 53.

Powell, F.L., S.C. Hempleman, G.S. Mitchell and H. Shams (1988). Ventilatory acclimatization to 3800 m in pekin ducks. The FASEB Journal, Vol. 2, A 1508.

Scheid, P. and H. Shams (1989). Role of vagus in thromboxane-mediated effects on respiration and pulmonary vascular-resistance in the anaesthetized cat. J. Physiol. (London) 125P.

Karla, W., H. Shams and P. Scheid (1991). Vagal reflexes and the cardiorespiratory effects evoked by thromboxane. Pflügers Arch. 418 (Suppl.): R 110.

Shams, H., W. Karla, J.A. Orr and P. Scheid (1992). Sensitivity of vagal afferent fibers to the prostanoid thromboxane A₂. In: Rhythmogenesis in Neurons and Networks. ed. by N. Elsner & D.W. Richter, Georg Thieme Verlag, Stuttgart, New York. 273H.

Orr, J. A., W. Karla, H. Shams and P. Scheid (1992). Stimulation of vagal afferent C-fibers by the thromboxane A₂ mimetic, U46,619. FASEB J. 6: A1229.

Herbst, C., B. Tippler, H. Shams and Th. Simmet (1994). Is endothelin involved in the pathogenesis of neurogenic pulmonary oedema? Naunyn-Schmiedeberg's Arch. Pharmacol. 394 (suppl.): R 290.

Herbst, C., B. Tippler, H. Shams and Th. Simmet (1995). Endothelin as a mediator in the bicuculine-induced neurogenic pulmonary oedema in rats. Pharmacological research. 31 (Suppl.).

Daffonchio, L., P. Geppetti, P. Javdan, H. Shams and G. Clavenna (1995). Mechanism of neuropeptide system inhibition in the lung: A study with levodropropizine. Pharmacological research. 31 (Suppl.).

Shams, H. (1997). CO₂ Effect on activity of the diaphragm during respiration with inspiratory pressure support. International Symposium on "Brain and breathing", Bochum, Germany.

Shams, H. and M.-C.Wellner-Kienitz (1997). Chemosensitive neurons in explant culture of fetal rat medulla. XXXIII International congress of physiological sciences